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The addition of allopurinol may help to protect the renal tubules from long-term damage due to uric acid crystallization. There is a case report of a patient with no history of psychiatric disease whose allopurinol-associated catatonia, rash, and fever responded to steroids. Allopurinol, which decreases the quantity of urate that reaches the kidneys in addition to decreasing the concentration of urate in the blood, is recommended in these circumstances {02} {05} {06} {07}. It is not known whether this potentiation of ampicillin rashes is due to allopurinol or the hyperuricemia present in these patients. Studies of patients with allopurinol-induced crystalluria and nephrolithiasis have revealed both urate and allopurinol/oxypurinol (allopurinol metabolite) calculi. Patients receiving azathioprine and allopurinol concomitantly should have a dose reduction of azathioprine to approximately 1/3 to 1/4 the usual dose. HypersensitivityA case study suggests cell-mediated immunity to allopurinol and oxypurinol is involved in allopurinol-induced hypersensitivity reactions. )generic name: allopurinol class: antigout agents, antihyperuricemic agents1 review(s)Rate It!9.

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